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In clinical trials, Semaglutide has demonstrated an average weight loss of about 15%

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Animal studies have revealed embryofetal toxicity at supratherapeutic doses

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Obesity pharmacotherapy from the @TheAACE diabetes algorithm: GLP1/GIP and GLP1 RAs produce ~1020% weight loss with A1c reduction, while older agents like phentermine, orlistat, and naltrexone/bupropion have less efficacy and safety tradeoffs

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