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In addition, TMAO induces several inflammatory pathways, which cause the activation of pro-inflammatory cytokines such as IL-6 and TNF- which causes chronic inflammation thereby causing plaque formation and plaque rupture leading to cardiovascular disease [71]

it is unknown whether these conditions exacerbate CIN-related ferroptosis by pre-disrupting iron homeostasis or antioxidant capacity, which limits the development of risk-stratified therapies

(2023) 186:27482764.e22

Similar content being viewed by others Introduction Obesity is the most prevalent chronic disease worldwide, now estimated to affect over 650 million people globally [1]