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Markedly reduced hepatic SOD activity has also been observed in many other diet-induced animal MASLD/MASH models, such as animals with a methionine-choline deficient diet, an iron-rich diet, monosodium glutamate (MSG)-induced obesity, lipopolysaccharide-induced liver injury as well as CCl 4 -induced liver injury (Alfarisi et al

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Alternate fuel substrates, such as ketones, can support cognitive acute performance improvements [11], while recovering insulin sensitivity and the ability to utilize glucose to meet brain energy demands is critical for long term prevention or slowing cognitive decline