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GHK-Cu directly stimulates fibroblasts (the cells that produce collagen) to increased synthesis of: Type I collagen , the main structural protein of skin, tendons, ligaments (+70 % in the Maquart 1988 studies) Type III collagen , a more flexible type for regenerative tissues Elastin , the protein responsible for the elasticity of skin Decorin and glycosaminoglycans , hyaluronan, dermatan sulfate In the dermatological area this explains the anti-wrinkle effect of GHK-Cu, restoration of the skins collagen structure, which weakens with age

In the analysis of dermoscopic factors, regression features were present independently of the patients' age and the pattern of facial melanoma was predominant in the elderly patients (28.5% vs

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Rizwana H, Aljowaie RM, Al Otibi F, et al