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Given the unprecedented potency of the new AOMs, there is a particular concern about pharmacotherapy-induced weight loss resulting in potentially excessive loss of lean mass, including skeletal muscle, especially in vulnerable patient populations, e.g., those at risk of sarcopenia the progressive loss of muscle mass, muscle quality and strength as a result of the human aging process

For some patients, the dose may be further increased to the maximum dose of 2 mg once weekly , depending on individual needs and physician recommendations

as the medication builds up to a steady state in your bloodstream, the signaling to your brain becomes more loud and persistent