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The loss of perineuronal nets in Alzheimers disease: missing or hiding in plain sight

A 63-year-old female with allergic and asthmatic symptoms since childhood, fibroids, Hashimotos thyroiditis, experienced diffuse body aches and bone pain, insomnia, brain fog, bloating, food sensitivities, and a need to eat every 23 hours

Intrathecal injection of exenatide (1-100 ng) elicited dose-dependent antinociception in formalin-induced tonic flinching responses without affecting acute nociceptive phases [24] (Fig