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Interestingly, as predicted by the Igfbp4-ko and the pappa-ko animal models described previously, a human PAPP-A2 gene defect with growth phenotype was recently reported as detailed below (43)

55,56 Nocturia can be a symptom of a medical condition, such as chronic kidney disease, diabetes, high blood pressure, congestive heart failure, chronic obstructive pulmonary disease, metabolic syndrome, or lower urinary tract problems such as prostate enlargement or overactive bladder

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