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Once the quantity of vitamin B12 that is absorbed in the body is sufficient, patients should notice a significant increase in their energy levels, an improvement in their overall cognitive functioning that may improve their memory and ability to think, as well as a considerable boost to their general mood

This "paradoxical response" (where treatment temporarily makes symptoms worse) includes: Numbness and tingling Shooting pains Joint pain Increased sensitivity Temporary inflammation (swelling and irritation) While these symptoms generally indicate that treatment is working (as nerves begin to repair themselves), they can be distressing for patients and may require additional treatment for comfort

The signs and symptoms of B12 deficiency differ widely

If your bacteriostatic water has been refrigerated, let it sit at room temperature for 15-20 minutes before reconstitution