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As a triple agonist targeting GLP-1, GIP, and glucagon receptors, retatrutide offers a mechanism uniquely suited to bodybuilding goals: - **GLP-1 receptor:** Reduces appetite and food intake essential for getting slim during a cutting phase - **GIP receptor:** May support lean mass preservation and nutrient partitioning relevant for muscle building goals - **Glucagon receptor:** Directly increases metabolic rate and fat oxidation a mechanism no GHRP bodybuilding peptide could match Phase 2 trial data published in *The Lancet* showed **up to 24.2% body weight reduction** with retatrutide the highest of any peptide injection studied to date

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While the impact of the GLP-1s is becoming well-understood in the public markets, fewer in the private markets are questioning how the proliferation of GLP-1s will affect their business model