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1 Results at nine months demonstrated that the combination of Sculptra and Restylane Lyft or Contour effectively improved the aesthetic appearance of patients experiencing facial volume loss associated with medication-driven weight loss, further supporting the benefits of the SHAPE Up HIT: 1 The combined Sculptra and Restylane Lyft or Contour regimen demonstrated skin quality improvements, with Restylane improving skin hydration and Sculptra significantly improving skin radiance through to Month 9 1 Subject satisfaction which was reported by the majority of patients as early as Week 4 was maintained through to Month 9: 1 85.7% of patients said their face looked less gaunt/sunken 1 88.6% said they loved how the treatment maintained their facial structure 1 88.6% of patients said they loved the regenerative effects of Sculptra treatment 1 88.6% felt they looked better than before the injection regimen 1 91.4% said they would recommend the injection regimen to others after weight loss and to those with loose, sagging facial skin 1 Safety was in line with previous pivotal trial data for Sculptra, Restylane Lyft and Contour, with no treatment-related adverse events reports

Additionally, a study showed the antiseizure effect of ALC (100 mg/kg) in the kainate murine model of temporal lobe epilepsy by attenuating status epilepticus and reducing oxidative stress and neuroinflammation (Tashakori-Miyanroudi et al., 2022)

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Research by Yu et al