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20 Three distinct groups of DPP4 inhibitors have been proposed based on the characterization of the binding mechanisms of the clinically most often used DPP4 inhibitors: Saxagliptin and vildagliptin, which belong to Class 1, engage with the S1- and S2 subsites of the active center and bind chemically to Ser630 of the DPP4 molecule

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However, for non-lean male patients, HbA1c and TG levels were significantly poorly controlled in NAFLD patients compared to those without NAFLD, while TG and LDL-C levels were significantly poorly controlled for non-lean female patients with NAFLD