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A negative trial result may indicate lack of drug access to the brain, rather than failure of the concept itself, Paul Edison, a professor of neuroscience at Imperial College London, explained

Unlike other weight loss medications that merely decrease appetite, Zepbound adopts a dual-action approach

More often than not, patients may need to try lower doses of the medication or an alternative class of GLP-1 agonists, as there is a variation in tolerability profile between them, says Criner

As the initial excitement fades, investors and patients alike are asking harder questions: Do these platforms deliver measurable, sustained health outcomes