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Previously, a study based on proteomic analysis had revealed marked transcriptional repression of other Nrf2-induced antioxidant proteins including CK2, ERK1/2, PKC, GPx, Mgst1, peroxiredoxin 3 (Prdx3), in both preclinical models and in human spinal MNs from ALS patients [253]

463 Similarly, in GBM, mesenchymal CSCs (CD44, CHI3L1) are strongly associated with hypoxic regions, suggesting an association between microenvironmental factors and CSC plasticity

B12 injections are necessary for confirmed pernicious anaemia, malabsorption conditions (such as Crohn's disease or following gastric surgery), or when neurological symptoms are present

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