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Patients should expect to feel a small pinch as we make the insertion points, but because the product is mixed with numbing lidocaine and most commonly injected with a blunt-tip cannula, the rest of the procedure feels like pressure, not pain

Melanotan-II is similar to a hormone in our bodies called melanocyte-stimulating hormone [MSH] that works to stimulate pigment production, says Joshua Zeichner, the director of cosmetic and clinical research in dermatology at Mount Sinai Hospital in New York City

Due to the burst of cooling cryogen spray that precedes the pulse of the laser, the treatment is comfortable

10.1016/j.biopha.2021.111862 48 HaitaoT.DuanhuaM.YuanyuanL.ShuifuT.YingL.GangyiC.et al (2021)