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Post-hoc power calculations (G*Power 3.1) using the reported effect sizes (Cohens d 0.250.40) indicate that 80% power to detect a minimal clinically important difference of 1 cm on the VAS pain scale would require 128200 completers per arm

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Melinda Ring, director of the Osher Center for Integrative Health at Northwestern University Feinberg School of Medicine, said the body naturally produces thousands of peptides, regulating "everything from hormone signaling to immune response and tissue repair." "And it does so through tightly controlled feedback mechanisms, in precise amounts," she explained

An effective dose of L-carnitine is considered to be 2g per day