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The Deseq2 package in R was employed for the calculation of log2 fold changes in transcript expression

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The addition of data from AMPLITUDE-O trial to the seven-trial meta-analysis [5] showed that patients with type 2 diabetes who received GLP-1 agonists had a decreased risk of MACE and decreased individual components (stroke more than myocardial infarction), independently of the structure of these drugs (exendine-4 based or human analogs)

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