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1 Introduction 1.1 Literature review methodology This review was conducted by searching PubMed, Scopus, and Google Scholar databases using the keywords Parkinsons disease, -synuclein, dopaminergic neurons, LRRK2, mitochondrial dysfunction, comorbidities, levodopa, and neuroinflammation. Studies published in English between 2000 and 2025 were included

doi: 10.1016/j.psyneuen.2010.10.001 58 GiardinaWJEbertDM

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Meta-analyses of clinical trials have shown high-intensity exercise in the hour before bedtime reduced REM sleep, increased the time needed to fall asleep, and reduced sleep duration and sleep efficiency in healthy young and middle-aged adults