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Dependent on the form of ADT used, build-up of steroid precursors occurs that are shunted to the synthesis of other steroids, such as progesterone (e.g., treatment with CYP17A1 inhibitor abiraterone), some of which can stimulate CaP progression via co-occurring accommodating changes in AR [35]

Reflects whole-body peptide effects but uncertain correlation with specific ocular mechanisms

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Molecular links between endocrine, nervous and immune system during chronic stress