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10.1101/cshperspect.a026781 86 HolmbergK

( E ) Phosphorylation of RPS6 at the S235/S236 sites after stimulation of blood with anti-IgE antibodies or with PN extract, normalized to unstimulated blood, in PN-allergic ( n = 73), nonallergic ( n = 18), PN-sensitized but tolerant ( n = 14), or PN-allergic basophils from nonresponder donors ( n = 6)

The inability to maintain reduced glutathione in RBCs leads to increased accumulation of peroxides, predominantly H 2 O 2 , that in turn results in a weakening of the cell wall as a result of membrane lipid peroxidation resulting in concomitant hemolysis