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Additionally, by phosphorylating p62, mTORC1 facilitates the binding of p62 and Keap1, which causes Keap1 to degrade and NRF2 to accumulate (107)

To those who are still bleating that we should keep trying diet and exercise before resorting to use of anti obesity medications or that we can maintain long term weight loss effected by use of medication by ceasing medication and relying on diet and exercise alone- please look up all the research which shows that lifestyle intervention alone can only effect 5-7% weight loss and this weight will also be regained in the next year or two