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however, evidence is emerging that increased cellular GSSG accumulation may be of equal, if not greater, importance in regulating oxidative stress-triggered detrimental effects

Scientific Reports , 10, 17078

And it has many social, commercial and environmental determinants, requiring action in many sectors not only in the clinic. These other determinants of obesity, such as a food environment rich in high sugar, fat, and salt foods, mean that the global overweight or obese population is expected to reach 60% by 2050