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Four interlocking changes define the midlife metabolic environment

Histological changes of SAMPUS are overlapping with dysplastic naevi (lentiginous proliferation of melanocytes with cytological atypia) however, additionally there is focal pagetoid spread of single or nested melanocytes (figures 14, 15)

The regulation of PFKFB3 in the physiology and pathology of some tissues has been confirmed by current studies, such as its role in regulating cell expression and viability in tumor tissues, and its role in insulin and inflammatory response in adipose tissues

Over the last 15 years, metformin has become the first-line agent for the treatment of type 2 diabetes, as noted in several international guidelines, including the ADA-EASD guidelines [3]