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Ethical approval and informed consent Not applicable: This study does not directly involve humans or animals

Melatonin supplementation alone, though, wasnt enough to return the AD mice to normal control levels, but the improvements were significant.[ref][ref][ref][ref] Another study using a mouse model of AD found that melatonin reduced the signs of Alzheimers, including cognitive deficits

Berberine has been studied in numerous trials, predominantly conducted in Asian populations, showing modest glucose-lowering effects comparable to metformin in some studies, with HbA1c reductions of approximately 0.5-1.0%

The potential neuroprotective effects of quercetin were also investigated by de Mattos et al., employing a prenatal VPA rat model of autism