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10.1038/s41568-018-0050-3 33 CavalliG.HeardE

There is a very important bond between the hypothalamic-pituitary-adrenal (HPA) axis and the sympathoadrenal system that allows them to interact with each other

The first is to add a prandial insulin to the treatment regimen, either by adding a RAI prior to the largest meal of the day, with addition at other meals in stages if required (basal-plus), adding RAI at all meals (basal-bolus), or by switching to a premixed (biphasic) insulin formulation of intermediate- and short-acting insulins

Insulin-like growth factor I of peripheral origin acts centrally to accelerate the initiation of female puberty