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The blood pressure-lowering effect appears to be primarily mediated through weight loss
GLP- 1's anti-apoptotic and proliferative effects are also mediated by the PI3 K/Akt axis through the transactivation of the epidermal growth factor receptor (EGFR), which is connected to GLP- 1 receptor through c-Src activation and the generation of endogenous EGF like ligands [59]
Diabetes Metab 34(Suppl 2):S65-72 [DOI] [PubMed] [Google Scholar] 15.Bass J, Tschp MH, Beutler LR (2023) Dual gut hormone receptor agonists for diabetes and obesity
Lee: GLP-1 agonists primarily affect the gastrointestinal system, but they also act on the brain, particularly the hypothalamus, which regulates many core functions, including hormones, temperature, and appetite
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