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Neuroimaging studies have shown that people taking GLP-1 drugs display reduced activation in reward regions of the brain when shown images of high-calorie foods, suggesting the drug actually changes how appealing certain foods seem

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To summarize, an ideal candidate mechanism for counteracting tendency for runaway dynamics imposed by Hebbian-type learning rules on weight changes of excitatory synapses and activity in interneurons should fulfill the following requirements

ROS are oxygen-containing compounds with unpaired electrons, including singlet oxygen, superoxide anions and hydroxyl radicals (19)