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Phenolic hydroxyl groups form hydrogen bonds with amino acid residues in the HDAC active site, and aromatic rings establish hydrophobic interactions and - stacking in the hydrophobic pocket to enhance binding affinity ( In vitro , ellagic acid exerts therapeutic effects on TNF--induced MH7A cells, with 50 M identified as the optimal dose

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Even if the usage of E2 as a therapeutic agent for human use is controversial, targeting specific ERs in the cardiovascular system could open new and perhaps safer therapeutic options for using E2 to protect the cardiovascular system [5] (Figure 1)

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