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These cyclic oligosaccharides form inclusion complexes with peptide molecules, temporarily increasing their aqueous solubility and facilitating transport across the nasal epithelium

Previous medications like Semaglutide (Wegovy/Ozempic) target only GLP-1, while Tirzepatide (Mounjaro/Zepbound) targets GLP-1 and GIP

In addition, the safety data from several large cardiovascular outcome studies have demonstrated no clear increased risk of pancreatitis or pancreatic cancer (7780)

[5] The initial differential diagnosis for hyposalivation reported in the 3 cases was dehydration and low water intake which was within the lower range of normal for both patients