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For example, the local use of diminazene aceturate in the treatment of endotoxic uveitis downregulated the mRNA expression levels of inflammatory factors and mediators, such as COX-2 and iNOS, in the iris and ciliary body

Systemic side effects include mild nausea, transient headache, dizziness, and increased heart rate in some patients

The integration of these three approaches at the level of the same sample will become an important direction for advancing this field from mechanistic research toward clinical translation (140)