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This can be a sign of underlying conditions like fibroids , endometriosis , or PCOS, which may disrupt the menstrual cycle

Symptoms of folate deficiency Some of the symptoms that can be caused by a lack of folate include: General symptoms Fatigue Irritability Headache Dizziness Gastrointestinal symptoms Sore tongue Mouth ulcers Diarrhea Loss of appetite Neurological symptoms Numbness and tingling in the hands and feet Confusion Depression Cognitive impairment Dementia Hematological symptoms Anemia (pale skin, shortness of breath) Testing for vitamin B12 and folate deficiency When to test Since vitamin B12 and folate affect many functions in the body and there are many possible symptoms, blood testing for vitamin B12 and folate is commonly ordered by the physicians at the Adult Down Syndrome Center

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For example, in one randomized, double-blind, placebo-controlled trial,54 1.5 mg/day of MK-4 for six to 12 months in postmenopausal women improved carboxylation of VKDPs (associated with bone health) and helped maintain bone mineral density