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A few commenters recommended that CMS conduct additional testing or simulation of the proposed methodology before full implementation, to allow for refinement and avoid confusion or disincentivizing reporting

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Efficacy and safety of LixiLan, a titratable fixed-ratio combination of insulin glargine plus Lixisenatide in type 2 diabetes inadequately controlled on basal insulin and metformin: the LixiLan-L randomized trial

These different mechanisms make sermorelin and BPC-157 complementary rather than competitive