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Distribution and Regulation of GLP-1 System Although a deficiency in GLP-1 is unlikely to directly impair the pathophysiology of T2DM, 20 reduced GLP-1 levels may contribute to the development of T2DM

To validate this effect in mice, we performed hyperinsulinemic-euglycemic clamps in Dpp4 +/+ (wild-type, WT) and Dpp4 / (global Dpp4 deletion) mice fed a high-fat, high-cholesterol (HFHC) diet for 12 weeks

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Prescription weight-management medications may be used (in combination with a reduced-calorie diet and increased physical activity) for people with one of the following conditions: A body mass index (BMI) of 30 or higher A BMI of 27 or higher with a weight-related condition, such as high blood pressure or type 2 diabetes GLP-1s and weight-management medications may also be prescribed for reasons outside of this list