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A 2015 study on the subject concluded that compared to "gastroresistant tablets" of identical dosage (e.g., liposomal and branded forms), 250mg of orobuccal glutathione led to "much quicker absorption and a considerably higher bioavailability" while producing "rapid onset of action."21 Another 2015 study comparing sublingual and oral routes of administration found the sublingual group exhibited higher total and reduced glutathione levels in plasma

A glutathione nutritional supplement formulation that utilizes innovative nutrient delivery nanotechnology can help overcome glutathiones absorption challenges and increase its bioavailability

Alimentary Pharmacology & Therapeutics, 17 (4), 595-601

The psychological impact of pill dysphagia: A mixed methods study