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Importantly, ZXGD could decrease these adverse factors such as HIF-1, ROS, IL-6, IL-1 and TNF-, while increase beneficial factors such as Nrf2 and IL-10, to relieve hypoxia, oxidative stress and inflammation to ameliorate pulmonary vascular remodeling in PH rats

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Breaking this down phonetically, the emphasis falls on the first syllable: 'RYE' (rhyming with 'eye' or 'pie'), followed by 'bell' (as in the ringing object), and ending with 'sus' (rhyming with 'bus' or 'fuss')