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Signaling pathways driving ulcerative colitis development and their associated therapeutic targets Given the complexity of UC, a comprehensive understanding of the signaling pathways that regulate UC pathogenesis is needed for the identification of potential therapeutic targets and the development of new treatments

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218 NF-B inhibitors can inhibit NF-B through different mechanisms, such as blocking the nuclear translocation of NF-B, inhibiting the activation of NF-B, and antagonizing the NF-B signaling pathway

Increased expression of ClpB does not affect appetite We next investigated the effects of a marked increase in E