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Several more lines of evidence derive from in vitro bio-mimetic studies and from experimental toxicology studies of inorganic and organic chemicals

Potential muscle-related effects include: Improved body composition Reduced visceral fat Mild increases in lean mass In a randomized, placebo-controlled study in HIV-infected adults with abdominal fat accumulation, daily subcutaneous tesamorelin for six months significantly reduced visceral adipose tissue compared with placebo and also increased trunk and total lean body mass, indicating improved overall body composition beyond just weight changes

No significant difference between the two intervention groups were found

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