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Estrogen decline can affect gut integrity and the microbiome, sometimes leading to bloating, food sensitivities, or leaky gut. A 2010 animal study found BPC-157 protected against gut lesions and accelerated healing in the stomach and intestines

Intragastric and oral administration give detectable plasma levels for several hours in rodent studies, supported by the proline-rich sequence resisting cleavage by gastric proteases