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Adrenergic blockade produced a significantly greater decrease in BP in obese than in lean patients with hypertension (Wofford et al., 2001), in line to the results reported with ganglionic blockade (Shibao et al., 2007)

The recommendations are consistent across the class

Cell Biochem 409 , 283305 (2015)

However, in A Diabetes Outcome Progression Trial (ADOPT), metformin exhibited a reduced risk of monotherapy failure compared with the sulfonylurea glibenclamide (known as glyburide in the USA and Canada) and slower rate of loss of beta cell function, although it was inferior to the thiazolidinedione rosiglitazone [20]