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Taken together, significant spine trauma creates an altered mechanical, cellular and metabolic status and may lead to cell death and malfunction of the disc compartments

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These taxa form a pathogenic synergistic network: Prevotella provides metabolic substrates through carbohydrate degradation, Fusobacterium enhances biofilm structural stability to facilitate persistent colonization, and Porphyromonas secretes virulence factors that damage periodontal tissues and suppress host immunity

Reference: FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway