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Apart from the beneficial effects and detrimental side effects of melanin production, melanocytes can also protect against microbial infections by acting as antigen-presenting cells producing cytokines, phagocytosing microorganisms, and degrading both phagocytosed bacteria and bacteria in the microenvironment by means of melanosomal lysosomal enzymes [4, 6, 7]

Diabetes with cardiovascular disease Cardiovascular disease (CVD) is a prevalent comorbidity in patients with diabetes, where T2DM patients are subject to a two- to three-fold increase in the risk of developing CVD, with a reported co-prevalence exceeding 30% [67, 68]

NCCN Guidelines insights: genetic/familial high-risk assessment: colorectal, version 1.2021

(1995): Selective activation of dopamine transmission in the shell of the nucleus accumbens by stress