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Lengthened intervals (forgetting doses) reduce the average drug exposure and can stall progress

According to Sarah McBane, PharmD, associate dean of pharmacy education at the University of California in Irvine, who specializes in womens health, the contraceptive warning specifically for tirzepatide may be because the medication is a dual agonist, meaning it acts on two gut hormones: glucagon-like peptide (GLP) and glucose-dependent insulinotropic polypeptide (GIP)

As a GIP/GLP-1 receptor agonist, tirzepatide enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying

A gallstone has moved from the gallbladder into the common bile duct, blocking bile flow