tirzepatide review Medics Reviews Medication Review: Describe The Mechanism

The Gerontologist, 55 (6), 901

However, the well-recognized pleotropic effects of GLP-1R agonists (normalization of neurogenesis and synaptic plasticity, protection against neuronal apoptosis, and suppression of increased oxidative stress), in conjunction with the presence of GLP-1Rs in the hypothalamic nuclei that regulate sleep and wakefulness, suggest several possible direct effects of GLP-1R agonists in affecting sleepiness and other related parameters (memory, anxiety, and depression) [77, 114]

Do not attempt to test degraded peptide by injecting it degraded MT2 fragments may bind non-selectively to melanocortin receptors, increasing side effect risk without therapeutic benefit

doi: 10.3390/nu17061010