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Obesity is a known risk factor for some inflammatory skin conditions, such as psoriasis and HS (167, 168)

Together, these hormones coordinate to regulate appetite, insulin and glucagon secretion, and nutrient metabolism, making them central to metabolic health

Synthesis of carnitine occurs in the kidney, liver and brain, and it is transported to other tissues in the circulation before it is taken up by tissues by carnitine transporters at the plasma membrane that are tissue-specific

For Zepbound patients who find the higher doses difficult to tolerate or afford, the SURMOUNT-MAINTAIN trial confirms that the lower 5 mg dose is an effective middle ground