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Research perspective A 2001 editorial in the European Journal of Anaesthesiology described DSIP as "incredibly safe" based on the lack of lethal doses in animal studies and absence of significant side effects in human trials beyond transient symptoms

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In this study, metformin did not alter oxidative phosphorylation or glycolysis in normal non-cancer rectal tissue biopsies, importantly suggesting that the anti-metabolic effects of metformin may be tumour tissue-specific, which supports its potential utility as a radiosensitiser in rectal cancer