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Natural product discovery: Past, present, and future

Therefore, cancer cells not only use FAO to oxidize fatty acids and to derive energy by mitochondria but they also use acetyl-CoA to endogenously synthesize fatty acids in the cytosol using NADPH as key cofactor for anabolic enzymes (Currie et al., 2013)

Over the past several decades, its prevalence has risen at an alarming rate worldwide, reaching pandemic proportions and showing no signs of stabilization [1, 2]