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Concretely, GPX4 uses GSH as the substrate to reduce phospholipid hydroperoxides (PLOOHs) to hydroxyl derivatives (PLOHs), and oxidizes GSH to GSSH, therefore alleviating the damage of oxidative stress to tumor cells (Stockwell, 2022)

Since each tissue type exhibits unique traits such as vascularization, immune profile, and biomechanical properties, tailored approaches are essential for optimal treatment