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These non-incretin metabolic peptides frequently exert effects on peripheral tissues such as skeletal muscle, adipose tissue, liver, and vasculature, and often engage receptors distinct from those targeted by current therapies

From a methodological standpoint, titration also allows researchers to test the durability of response

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Studies have shown that in humans, intravenous injections of arginine (30 g per 30 min) can cause a 72-fold increase in the plasma levels of arginine (100 mol/L to 7200 mol/L), accompanied by a 15% decrease in blood pressure (28)