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At clinical concentrations, pretomanid does not inhibit major CYP isoenzymes, including CYP1A2, CYP2C8, CYP2C9, CYP2C19 or CYP2D6, and does not induce CYP2C9 or CYP3A4, limiting the potential for DDI trough CYPs
This variant significantly In addition, TT variant exhibits reduces enzyme activityby approximately 70% in TT homozygotes
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Tesamorelin is a synthetic growth hormone-releasing hormone analogue licensed in the United States for HIV-associated lipodystrophy, but unlicensed in the UK
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