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The rationale for combining NAD+ precursors with tirzepatide is similar to that for niacinamide, but with potentially greater potency due to higher NAD+ bioavailability

Furthermore, IGF-1 increased extensor digitorum longus (EDL) and soleus muscle masses of dystrophic mice by 20% and 29%, respectively, as compared with untreated dystrophic controls [77]

HLCs: hepatocyte-like cells