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Weight loss was accompanied by improvements in cardiometabolic parameters, including a decrease in systolic blood pressure (-9.9 mmHg) and waist circumference (-17.5 cm) (placebo-adjusted: 6.7 mmHg and 13.5 cm, respectively)

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The results of this systematic review and meta-analysis demonstrate that glucagon-like peptide-1 receptor agonists (GLP-1RAs) reduce the risk of major adverse cardiovascular events (MACE)

Directly, GLP-1 RAs may lower inflammatory cytokine production, blunt Toll-like receptormediated responses to bacterial stimuli, and promote tissue repair by reducing matrix metalloproteinases, offering a plausible immunomodulatory benefit beyond weight change alone